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The association between prehospital HMGB1 and sepsis in emergency care

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More than 750 000 Americans are hospitalized with sepsis annually, and one in five patients may not survive [1]. Emergency medical services (EMS) provide essential care for more than half… Click to show full abstract

More than 750 000 Americans are hospitalized with sepsis annually, and one in five patients may not survive [1]. Emergency medical services (EMS) provide essential care for more than half of hospitalized sepsis patients, yet the diagnosis of sepsis may be delayed or missed. However, the prehospital interval is a key opportunity for early sepsis recognition, initiation of treatment and emergency department (ED) notification [2]. Prior prehospital studies developed sepsis recognition models based on subjective data and vital signs with limited success [3,4].

Keywords: sepsis; emergency; hmgb1 sepsis; association prehospital; care; prehospital hmgb1

Journal Title: European Journal of Emergency Medicine
Year Published: 2022

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