appropriate therapeutic strategy (PRRT versus chemotherapy versus chemo-PRRT). Such clinical exercise is a valuable complimentary procedure to pathology (Ki-67/ MIB-1 labelling index) in major NET clinics/centres. It must be emphasized… Click to show full abstract
appropriate therapeutic strategy (PRRT versus chemotherapy versus chemo-PRRT). Such clinical exercise is a valuable complimentary procedure to pathology (Ki-67/ MIB-1 labelling index) in major NET clinics/centres. It must be emphasized here that the Ki-67/MIB-1 labelling index is a singular number, though invaluable for characterization of NET, may be fraught with the shortcoming of its inability to assess the tumour biology on a continuous scale in a real-life scenario, particularly in the borderline ranges. Dual tracer PET-CT characteristics based upon relative tracer accumulation on somatostatin receptor expression (by Ga-DOTA-TATE/NOC PET-CT) and tumour glycolysis [by fluorodeoxyglucose (FDG)PET/CT], on the other hand, is able to depict tumour biology/phenotype on a continuous scale and thus offers potential advantages over a single cross-sectional/cut-off value of Ki-67/MIB-1 labelling index in disease characterization [5].
               
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