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The published physiological distribution of prostate-specific membrane antigen (PSMA) PET ligands includes normal uptake in the lacrimal glands, salivary glands, bowel, liver, spleen, kidneys and parasympathetic ganglia but does not… Click to show full abstract
The published physiological distribution of prostate-specific membrane antigen (PSMA) PET ligands includes normal uptake in the lacrimal glands, salivary glands, bowel, liver, spleen, kidneys and parasympathetic ganglia but does not include the epididymis. Using a latest-generation digital PET scanner, we report physiologic PSMA radiotracer uptake in the epididymal head region as a new physiological variant presented in a case series of 134 PSMA-targeted 2-(3-(1-carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl)-ureido)-pentanedioic acid (18F-DCFPyL) PET/computed tomography (CT) scans. The high spatial resolution of digital PET/CT is the most likely explanation for the apparent 'novelty' of this epididymal normal variant, which is associated with higher serum testosterone levels.
Journal Title: Nuclear Medicine Communications
Year Published: 2020
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