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Importance of pharmacologic considerations in the development of targeted anticancer agents for children

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Purpose of review The purpose of this review is to describe key pharmacologic considerations to inform strategies in drug development for pediatric cancer. Recent findings Main themes that will be… Click to show full abstract

Purpose of review The purpose of this review is to describe key pharmacologic considerations to inform strategies in drug development for pediatric cancer. Recent findings Main themes that will be discussed include considering patient specific factors, epigenetic/genetic tumor context, and drug schedule when optimizing protocols to treat pediatric cancers. Summary Considering these factors will allow us to more effectively translate novel targeted therapies to benefit pediatric patients.

Keywords: development; development targeted; importance pharmacologic; targeted anticancer; pharmacologic considerations; considerations development

Journal Title: Current Opinion in Pediatrics
Year Published: 2022

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