LAUSR

endothelium efficiently endocytosed stabilin ligand (Formaldehyde-treated boivine serum albumin [FT-BSA]) (not shown), whereas only few cells in mouse pancreatic islets endocytosed the ligand (Fig. 1B). NODmice did not have insulitis inmost islets, but neither immune nor endocrine cells were positive for the stabilins by immunostaining. Weak occasional staining was seen in islet endothelial cells (not shown). In human pancreas, islet microvascular endothelial cells were strongly positive for both stabilins, and there were also some stabilin-expressing cells scattered in the exocrine parenchyma (Fig. 1C, D).