After 1 month, pruritus disappeared and sBA normalized (4.6 mmol/L). Follow-up at 3 and 8 months confirmed the absence of pruritus and cholestasis (sBA: 1.9 and 5 mmol/L). Serum liver… Click to show full abstract
After 1 month, pruritus disappeared and sBA normalized (4.6 mmol/L). Follow-up at 3 and 8 months confirmed the absence of pruritus and cholestasis (sBA: 1.9 and 5 mmol/L). Serum liver tests, alpha-fetoprotein level, and liver elastography value (Supersonic Shear Imaging: 6 kPa) were normal. This report shows that in our PFIC2 patient GPB is as efficient as PBA to improve pruritus and cholestasis and allows good oral tolerance and therapeutic adherence.
               
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