LAUSR

BACKGROUND Little is known about ileal motility patterns and their utility in children. Here, we present our experience with children undergoing ileal manometry (IM). METHODS A retrospective review of children with ileostomy comparing IM between two groups: A (chronic intestinal pseudo-obstruction [CIPO]) and B (feasibility of ileostomy closure in children with defecation disorders). We also compared the IM findings with those from antroduodenal manometry (ADM), and evaluated the joint effect of age, sex, and study indication group on IM results. RESULTS A total of 27 children (median age 5.8 years old, range 0.5 to 16.74 years, 16 were female) were included (12 in group A and 15 in group B). There was no association between IM interpretation and sex; however younger age was associated with abnormal IM (p=0.021). We found a significantly higher proportion of patients with presence of phase III of the migrating motor complex (MMC) during fasting and normal post-prandial response in group B than in group A (p<0.001). Logistic regression analysis revealed that only Group B was associated with normal IM (p<0.001). We found a moderate agreement for the presence of phase III MMC and postprandial response between IM and ADM (k=0.698, p=0.008 and k=0.683, p=0.009, respectively). CONCLUSION Ileal manometry is abnormal in patients with CIPO and normal in patients with defecation disorders, suggesting that ileal manometry may be not needed for ostomy closure in those with defecation disorders. IM has a moderate agreement with ADM and could be used as a surrogate for small bowel motility.