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Unfractionated Heparins, Low-Molecular-Weight Heparins, and Indirect Factor Xa Inhibitors in Plastic and Reconstructive Surgery: An Evidence-Based Review.

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SUMMARY Venous thromboembolism can present with devastating complications and sequalae, particularly in the surgical patient. Current data supports prophylactic anticoagulant use in the high-risk inpatient, defined as those with a… Click to show full abstract

SUMMARY Venous thromboembolism can present with devastating complications and sequalae, particularly in the surgical patient. Current data supports prophylactic anticoagulant use in the high-risk inpatient, defined as those with a 2005 Caprini Risk Assessment Model score of ≥7. The most utilized chemoprophylaxis agents include unfractionated heparin, low-molecular-weight heparins, and indirect factor Xa inhibitors. The authors review their mechanisms of action, metabolism, reversal agents, indications, contraindications, advantages, and disadvantages in plastic and reconstructive surgery.

Keywords: plastic reconstructive; weight heparins; molecular weight; reconstructive surgery; low molecular

Journal Title: Plastic and reconstructive surgery
Year Published: 2023

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