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Risk of hepatocellular carcinoma after DAA treatment in cirrhotic HIV-HCV-coinfected patients: where do we stand?

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Together with the increase in life expectancy of HIVinfected individuals with antiretroviral therapy (ART), morbidity and mortality from liver disease has sharply increased in individuals coinfected with hepatitis C or… Click to show full abstract

Together with the increase in life expectancy of HIVinfected individuals with antiretroviral therapy (ART), morbidity and mortality from liver disease has sharply increased in individuals coinfected with hepatitis C or B and exhibit advanced liver fibrosis and cirrhosis [1,2]. Since 2009, hepatocellular carcinoma (HCC) has emerged as a more common feature of end-stage liver disease in this population [3] and a recent retrospective multicohort analysis reported an increase in HCC by 11% per calendar year between 2001 and 2014, with an incidence of 1.6 [95% confidence interval (CI)1⁄4 1.3– 2.0] cases per 1000 person-years of follow-up [4].

Keywords: hepatocellular carcinoma; carcinoma; treatment cirrhotic; risk hepatocellular; carcinoma daa; daa treatment

Journal Title: AIDS
Year Published: 2018

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