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Elite suppressors have low frequencies of intact HIV-1 proviral DNA.

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: Elite controllers or suppressors (ES) control viral replication without antiretroviral therapy (ART). We used the intact proviral DNA assay to approximate the size of the inducible latent reservoir in… Click to show full abstract

: Elite controllers or suppressors (ES) control viral replication without antiretroviral therapy (ART). We used the intact proviral DNA assay to approximate the size of the inducible latent reservoir in ES and found that while the median frequency of both total and intact proviral DNA was markedly lower than the frequencies seen in chronic progressors (CP) on ART, there was no significant difference in the ratio of intact to total proviral DNA between ES and CP.

Keywords: low frequencies; dna; frequencies intact; suppressors low; elite suppressors; proviral dna

Journal Title: AIDS
Year Published: 2019

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