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Human CD300a is known to promote the infection by Dengue and other enveloped viruses and is overexpressed on CD4+ T cells from HIV-1 infected patients. We found that infected CD4+RA-… Click to show full abstract
Human CD300a is known to promote the infection by Dengue and other enveloped viruses and is overexpressed on CD4+ T cells from HIV-1 infected patients. We found that infected CD4+RA- T cells from untreated HIV-1 infected patients were mostly CD300a+. Furthermore, CD300a expressing CD4+RA- T cells from healthy donors were significantly more infected by HIV-1 in vitro than CD300a- cells. CD300a might represent a biomarker of susceptibility to HIV-1 infection on memory CD4+ T lymphocytes.
Keywords:
hiv infection;
susceptibility hiv;
cd300a;
infection;
cd4
Journal Title: AIDS
Year Published: 2020
Link to full text (if available)
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Journal Title: AIDS
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!