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Prominent 68Ga-FAPI Uptake in Renal Parenchyma Caused by Immunoglobulin G4-Related Nephropathy.

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ABSTRACT A 57-year-old man presented with a dry cough and renal insufficiency. Serum immunoglobulin G4 (IgG4) level was markedly elevated, and IgG4-related disease was clinically considered. 18F-FDG PET/CT revealed mild… Click to show full abstract

ABSTRACT A 57-year-old man presented with a dry cough and renal insufficiency. Serum immunoglobulin G4 (IgG4) level was markedly elevated, and IgG4-related disease was clinically considered. 18F-FDG PET/CT revealed mild uptake in salivary glands and also moderately increased activity in renal parenchyma and prostate. 68Ga-FAPI PET/CT detected prominent and evenly distributed 68Ga-FAPI uptake in the kidney, and the pancreas, salivary gland, and prostate also showed intense activity, consistent with IgG4-related disease involving the kidney, pancreas, salivary gland, and prostate.

Keywords: fapi uptake; uptake renal; 68ga fapi; prominent 68ga; renal parenchyma

Journal Title: Clinical nuclear medicine
Year Published: 2023

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