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Importantly, we get no information on the specific use, composition, and site of the epidural analgesia, which may influence ileus duration. Even more important, we get no information on the… Click to show full abstract
Importantly, we get no information on the specific use, composition, and site of the epidural analgesia, which may influence ileus duration. Even more important, we get no information on the perioperative use of opioids in the 2 groups and where alvimopan is supposed to be effective only when using opioids. Finally, there was also a skewness in the type of procedures with a tendency toward more ‘‘easy’’ procedures in the alvimopan group. Although a statistical exercise with multivariate analysis was employed, but not discussed in detail, there may be too many important confounders to allow their conclusion, also compared to other published data from fully implemented enhanced recovery programs without alvimopan.
Journal Title: Annals of Surgery
Year Published: 2017
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