LAUSR

BACKGROUND Donors with drowning or asphyxiation (DA) as a mechanism of death (MOD) are considered high risk in pediatric lung transplantation. We sought to evaluate whether recipients of DA donors had negatively impacted outcomes. METHODS Pediatric recipients recorded in the United Network for Organ Sharing (UNOS) registry between 2000 and 2019 were included. Primary stratification was donor MOD. Propensity-matching with a 1:1 ratio was performed to balance the DA and non-DA MOD donor cohorts. Cox multivariable regression was used to determine the risk-adjusted impact of donor MOD. A subanalysis of the effect of lung allocation score (LAS) was also evaluated. RESULTS 1016 patients underwent bilateral lung transplantation during the study period, including 888 (85.6%) from non-DA donors and 128 (14.4%) from DA donors. Survival at 90-days, 1-year and 2-years were similar in the matched and unmatched cohorts regardless of the donor MOD. Moreover, separate risk-adjusted analysis of drowning and asphyxiated donors was similar to other MOD donors at 30-days, 1-year, and 5-years. Similar survival findings persisted regardless of pretransplant LAS. Although the rates of posttransplant stroke (1.0% vs 3.1%, p=0.04) and the length of hospital stay (19 vs 22 days, p=0.004) were elevated in the unmatched DA MOD recipients, these differences were mitigated after propensity matching. CONCLUSIONS This study evaluated the impact of DA MOD donors in pediatric lung transplant recipients and found similar rates of complications and survival in a propensity matched cohort. These data collectively support the consideration of DA MOD donors for use in pediatric lung transplantation.