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Lung Transplantation From Donation After Brain Death Donors on Extracorporeal Support

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S hortage of lung donors has led transplantation pro-grams to work on new approaches to getting potential donors. In contrast, lung transplant surgeons face the advances in treatments for critically… Click to show full abstract

S hortage of lung donors has led transplantation pro-grams to work on new approaches to getting potential donors. In contrast, lung transplant surgeons face the advances in treatments for critically ill patients, includ-ing the increased use of extracorporeal membrane oxygenation (ECMO) support. The use of donors on ECMO raises some concerns: endothelial injury and pulmonary edema because of extracorporeal circulation-induced systemic inflammatory response syndrome; pulmonary congestion, caused by increased left ventricle afterload (venoarterial ECMO); alveolar hemorrhage induced by pulmonary edema; and anticoagulation therapies. 1 Also, the criteria for determination of death and the assessment of graft quality are challenging in potential donors on ECMO. 2 We report the experience of lung recipients from donors after neurological determination of death (DBD) while on ECMO support from 3 centers of the European

Keywords: lung transplantation; lung; death; transplantation; support; transplantation donation

Journal Title: Transplantation
Year Published: 2022

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