S of heart transplantation (HTx) candidates should take into account the need and the probability of success of transplantation. The output of a process that is focused on the careful… Click to show full abstract
S of heart transplantation (HTx) candidates should take into account the need and the probability of success of transplantation. The output of a process that is focused on the careful evaluation of individuals, per international experts' recommendations, is by the end, the building of a group, because each patient that is deemed eligible and deserving of an HTx is added to the others on a transplant waitlist. Conversely, organ allocation criteria are defined within each country, considering ethical principles and societal values besides strictly medical considerations. The output of this process is the assignment of single hearts to single patients. Balancing the best interests of individual with a community's interests may be a difficult task when the gap between demand and supply is wide, as in the case with HTx. Local heart allocation per the “first come, first serve” rule has been progressively abandoned in favor of broader organ sharing and urgency-based prioritization to reduce inequalities and meet the patient needs (Table 1). The increasing proportion of patients undergoing HTx in critical conditions could limit posttransplant survival without reducing the waitlist mortality, ultimately worsening overall patient outcomes. In this issue, Cantrelle et al analyzed 1-year mortality in patients listed for HTx in France from 2010 to 2013, with the aim to distinguish patient-related predictors and the influence of allocation policy. Of the 2053 candidates, two thirds underwent HTx within 1 year, and a quarter died while waiting for transplantation, with half of them passing away in the first year. Independent predictors for death
               
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