The fabrication conditions of bone-haemostasis sheet were examined by using (i) phosphoryl oligosaccharides of calcium (POs-Ca), sugar-containing hydroxyapatite (s-Ca10(PO4)6(OH)2: s-HAp) derived from POs-Ca and (ii) natural plant-derived polymers (locust bean… Click to show full abstract
The fabrication conditions of bone-haemostasis sheet were examined by using (i) phosphoryl oligosaccharides of calcium (POs-Ca), sugar-containing hydroxyapatite (s-Ca10(PO4)6(OH)2: s-HAp) derived from POs-Ca and (ii) natural plant-derived polymers (locust bean gum (LBG), guar gum (GG) and alginate (AG)). The sol, which had been prepared by dissolving 2 mass% LBG/GG and 2 mass% AG into 200 cm3 deionized water and then by agitating at the speed of 20 000 r.p.m., was immersed into 3 mass% POs-Ca solution at room temperature for 24 h; it was hydrothermally treated at 100°C for 5 h, and then freeze-dried at −50°C for 24 h to form porous composite sheet. The microscopic observation showed that the pore sizes were controlled in the range of 5–100 µm by the optimization of LBG/GG ratio. The composite sheet showed the noted uptake of simulated body fluid (1426%) at 37.0°C and also the human blood. Thus, the porous composite sheet was found to be a promising candidate of the bone haemostasis, on the basis of the data of haemostasis, uptake ability of SBF and solubility in acetic acid–sodium acetate buffer solution.
               
Click one of the above tabs to view related content.