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Alpha-linolenic acid-modified liposomes associate with and modulate antibiotic activity against Helicobacter pylori

Graphical Abstract Summary of key findings: (1) Linolenic acid (αLA) was effective in killing Helicobacter pylori, but not Escherichia coli or Campylobacter jejuni. (2) Liposomes encapsulating αLA and amoxicillin had… Click to show full abstract

Graphical Abstract Summary of key findings: (1) Linolenic acid (αLA) was effective in killing Helicobacter pylori, but not Escherichia coli or Campylobacter jejuni. (2) Liposomes encapsulating αLA and amoxicillin had greatly enhanced bactericidal activity against H. pylori, compared to liposomes containing just one of these components, or amoxicillin in solution. (3) Liposomes encapsulating αLA rapidly bound to H. pylori at higher densities compared to liposomes without αLA. Created in BioRender. Robinson, K. (2025) a31l841 https://BioRender.com.

Keywords: pylori; helicobacter pylori; alpha linolenic; linolenic acid; activity

Journal Title: Microbiology
Year Published: 2025

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