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Figure 4. Mouse CPEB-3 is required for both normal long-term potentiation in the hippocampus and maintenance of long-term spatial memory. (A) Mouse CPEB-3 is required for the maintenance of protein… Click to show full abstract
Figure 4. Mouse CPEB-3 is required for both normal long-term potentiation in the hippocampus and maintenance of long-term spatial memory. (A) Mouse CPEB-3 is required for the maintenance of protein synthesis– dependent long-term potentiation (LTP) induced by strong tetanic stimulation (4 × 100 Hz), but is dispensable for early-phase LTP induced by a single 100 Hz train. (B) Conditional deletion of CPEB-3 by injection of a Cre recombinase lentivirus into the mouse hippocampus prevents reconsolidation following memory retrieval.
Journal Title: Cold Spring Harbor perspectives in biology
Year Published: 2017
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