LAUSR

Molecular motors move in a dynamic environment of the cytoskeleton which generates fluctuations exceeding the thermal agitation. Their efficient motility and force generation are generally achieved via complex gating and coupling mechanisms between chemical steps, conformational changes, and mechanical steps in the working cycle. However, the motors display various force-velocity relations seemingly related (also) to the asymmetry of their unbinding from the track depending on the direction of the applied force. Here we study theoretically how the motility of molecular motors changes when they operate under an oscillating external force. We explore the roles of the shape of the force-velocity relation and the asymmetry of the force-induced unbinding. We find that a motor speeds up under force oscillations if its unbinding has a strong load dependence and a moderate asymmetry with respect to the direction of load. Motors whose unbinding is slowed down under hindering forces withstand average loads higher than the usual stall force. The relation between the function, unbinding properties, and predicted responses to the oscillating force supports the idea that the asymmetry of the load induced unbinding could serve as an adaptation of motors to their different physiological functions.