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An infrared free-electron laser was applied to dissociate amyloid fibrils of a peptide as a goal of the development of a novel therapeutic strategy for amyloidosis. Solid evidence for β-sheet… Click to show full abstract
An infrared free-electron laser was applied to dissociate amyloid fibrils of a peptide as a goal of the development of a novel therapeutic strategy for amyloidosis. Solid evidence for β-sheet to α-helix conversion in the peptide fibril by vibrational excitation of amide bonds was obtained by both experiment and molecular dynamics simulation.
Keywords:
free electron;
development;
application study;
amyloidosis;
infrared free
Journal Title: Journal of Synchrotron Radiation
Year Published: 2022
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Journal Title: Journal of Synchrotron Radiation
Year Published: 2022
Link to full text (if available)
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recommendations!