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Single-particle cryo-EM using alignment by classification (ABC): the structure of Lumbricus terrestris haemoglobin

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An efficient and fast pipeline is presented for obtaining near-atomic resolution structures from large single-particle cryo-EM data sets. The approach is virtually reference-free and is therefore less prone to the… Click to show full abstract

An efficient and fast pipeline is presented for obtaining near-atomic resolution structures from large single-particle cryo-EM data sets. The approach is virtually reference-free and is therefore less prone to the perils of reference bias.

Keywords: using alignment; cryo using; single particle; particle cryo

Journal Title: IUCrJ
Year Published: 2017

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