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Symmetry breaking by enzyme-catalyzed epoxide hydrolysis

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Janfalk Carlsson et al. [IUCrJ (2018), 5, 269–282] describe studies on factors determining selective ring opening of methylstyrene oxide stereoisomers by the epoxide hydrolase StEH1. The stereo-differentiating step is selective… Click to show full abstract

Janfalk Carlsson et al. [IUCrJ (2018), 5, 269–282] describe studies on factors determining selective ring opening of methylstyrene oxide stereoisomers by the epoxide hydrolase StEH1. The stereo-differentiating step is selective hydrolysis of an alkylated intermediate formed by reaction of the epoxide with an aspartyl residue.

Keywords: epoxide hydrolysis; catalyzed epoxide; breaking enzyme; hydrolysis; symmetry breaking; enzyme catalyzed

Journal Title: IUCrJ
Year Published: 2018

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