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TsNirK is the first three-copper three-domain nitrite reductase harbouring Gln-coordinated type 1 copper centres. All the structural properties of TsNirK point to an enzyme that, despite having several of the… Click to show full abstract
TsNirK is the first three-copper three-domain nitrite reductase harbouring Gln-coordinated type 1 copper centres. All the structural properties of TsNirK point to an enzyme that, despite having several of the essential catalytic features present in other NirKs, shows two distinctive and unique characteristics: firstly, the putative T1CuC → T1CuN → T2Cu electron-transfer pathway along the same subunit; and secondly, more importantly, is the presence of the SerCAT residue at the enzyme substrate sensing loop, which opens a new paradigm in this widely studied family of enzymes.
Journal Title: IUCrJ
Year Published: 2019
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