Cryo-EM reconstruction of the native Torpedo membrane reveals that cholesterol segregates preferentially around nicotinic acetylcholine receptors, interacting robustly with specific transmembrane sites and creating a network of bridging microdomains. The… Click to show full abstract
Cryo-EM reconstruction of the native Torpedo membrane reveals that cholesterol segregates preferentially around nicotinic acetylcholine receptors, interacting robustly with specific transmembrane sites and creating a network of bridging microdomains. The microdomains may promote cooperativity between neighbouring receptors, leading to an enhanced postsynaptic response.
Keywords:
architecture cholinergic;
protein lipid;
cholinergic postsynaptic;
membrane;
lipid architecture;
postsynaptic membrane
Journal Title: IUCrJ
Year Published: 2020
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Journal Title: IUCrJ
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!