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Structural insights into the histidine-containing phosphotransfer protein and receiver domain of sensor histidine kinase suggest a complex model in the two-component regulatory system in Pseudomonas aeruginosa

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Two crystal structures of the histidine-containing phosphotransfer protein (HptB) and the receiver domain of the hybrid sensor histidine kinase PA1611 (PA1611REC) in the two-component regulatory system of Pseudomonas aeruginosa have… Click to show full abstract

Two crystal structures of the histidine-containing phosphotransfer protein (HptB) and the receiver domain of the hybrid sensor histidine kinase PA1611 (PA1611REC) in the two-component regulatory system of Pseudomonas aeruginosa have been determined. With the modeled structure of the PA1611REC/HptB complex, the interactions and phosphoryl group transfer between HptB and PA1611REC are elucidated.

Keywords: phosphotransfer protein; receiver domain; sensor histidine; histidine; histidine containing; containing phosphotransfer

Journal Title: IUCrJ
Year Published: 2020

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