A series of multicomponent cocrystal solvates of chiral dihydromyricetin with caffeine (CAF) or theophylline (THE) crystallized as two distinct types of solid solution differing in mixing scale of enantiomers spanning… Click to show full abstract
A series of multicomponent cocrystal solvates of chiral dihydromyricetin with caffeine (CAF) or theophylline (THE) crystallized as two distinct types of solid solution differing in mixing scale of enantiomers spanning several orders of magnitude. This remarkable impact on enantiomer discrimination was simply achieved by the reduction of a methyl group of CAF to the THE coformer, which was attributed to the hydrogen-bonding donor–acceptor capacity coformers.
               
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