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The EF-hands within the crystal structures of the Zn2+-bound EFhd1 and EFhd2 core domains coordinate Zn2+ ions. EFhd1 and EFhd2 exhibited Ca2+- and Zn2+-independent actin binding and Ca2+- and Zn2+-dependent… Click to show full abstract
The EF-hands within the crystal structures of the Zn2+-bound EFhd1 and EFhd2 core domains coordinate Zn2+ ions. EFhd1 and EFhd2 exhibited Ca2+- and Zn2+-independent actin binding and Ca2+- and Zn2+-dependent actin-bundling activity, and these suggest the possibility that both Ca2+ and Zn2+ act to regulate EFhd1 and EFhd2 in physiological processes.
Keywords:
ca2 zn2;
biochemical insights;
zn2 bound;
structural biochemical;
zn2;
efhd1 efhd2
Journal Title: IUCrJ
Year Published: 2023
Link to full text (if available)
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Journal Title: IUCrJ
Year Published: 2023
Link to full text (if available)
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recommendations!