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A modified synthesis procedure allowed lapachol acetate (acetic acid 3-(3-methyl-but-2-enyl)-1,4-dioxo-1,4-dihydro- naphthalen-2-yl ester) to be obtained in high yield and its crystal structure is reported for the first time 80 years… Click to show full abstract
A modified synthesis procedure allowed lapachol acetate (acetic acid 3-(3-methyl-but-2-enyl)-1,4-dioxo-1,4-dihydro- naphthalen-2-yl ester) to be obtained in high yield and its crystal structure is reported for the first time 80 years after its first synthesis. The lapachol acetate molecular conformation is very similar to that of reported lapachol molecules and other derivatives. The monoclinic P21/n crystal structure packs through weak intermolecular π–π and C—H⋯O interactions as described by Hirshfeld surface analysis.
Journal Title: Acta Crystallographica Section E: Crystallographic Communications
Year Published: 2019
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