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Purpose: During the COVID-19 pandemic, the three-dimensional (3D) printing community is actively participating to address the supply chain gap of essential medical supplies such as face masks, face shields, door adapters, test swabs and ventilator valves This paper aims to present a comprehensive study on the role of 3D printing during the coronavirus (COVID-19) pandemic, its safety and its challenges Design/methodology/approach: This review paper focuses on the applications of 3D printing in the fight against COVID-19 along with the safety and challenges associated with 3D printing to fight COVID-19 The literature presented in this paper is collected from the journal indexing engines including Scopus, Google Scholar, ResearchGate, PubMed, Web of Science, etc The main keywords used for searches were 3D printing COVID-19, Safety of 3D printed parts, Sustainability of 3D printing, etc Further possible iterations of the keywords were used to collect the literature Findings: The applications of 3D printing in the fight against COVID-19 are 3D printed face masks, shields, ventilator valves, test swabs, drug deliveries and hands-free door adapters As most of these measures are implemented hastily, the safety and reliability of these parts often lacked approval The safety concerns include the safety of the printed parts, operators and secondary personnel such as the workers in material preparation and transportation The future challenges include sustainability of the process, long term supply chain, intellectual property and royalty-free models, etc Originality/value: This paper presents a comprehensive study on the applications of 3D printing in the fight against COVID-19 with emphasis on the safety and challenges in it © 2020, Emerald Publishing Limited