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Purpose This paper aims to provide a technical insight into recent molecular sensor developments involving nanophotonic materials and phenomena. Design/methodology/approach Following an introduction, this highlights a selection of recent research activities involving molecular sensors based on nanophotonic technologies. It discusses chemical sensors, gas sensors and finally the role of nanophotonics in Raman spectroscopy. Brief concluding comments are drawn. Findings This shows that nanophotonic technologies are being applied to a diversity of molecular sensors and have the potential to yield devices with enhanced features such as higher sensitivity and reduced size. As several of these sensors can be fabricated with CMOS technology, potential exists for mass-production and significantly reduced costs. Originality/value This article illustrates how emerging nanophotonic technologies are set to enhance the capabilities of a diverse range of molecular sensors.