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Carbon Nanotube Field-Effect Transistor With Vacuum Gate Dielectric for Label-Free Detection of DNA Molecules: A Computational Investigation

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In this paper, we assess the performance of a new label-free deoxyribonucleic acid (DNA) nanosensor based on ballistic carbon nanotube field-effect transistor (CNTFET). The proposed label-free biosensor employs the mechanism… Click to show full abstract

In this paper, we assess the performance of a new label-free deoxyribonucleic acid (DNA) nanosensor based on ballistic carbon nanotube field-effect transistor (CNTFET). The proposed label-free biosensor employs the mechanism of an ultrascaled CNTFET in conjunction with the dielectric and charge modulation concept to electronically detect the neutralized and charged DNA molecules. The proposed DNA nanosensor is endowed with a sensitive channel based on a zigzag carbon nanotube (Z-CNT). The investigation is based on a rigorous quantum simulation, which solves self-consistently the Schrödinger and Poisson equations within the non-equilibrium Green’s function (NEGF) formalism framework. The threshold voltage shift is considered as a biosensing metric. The simulation study includes the potential distribution, Z-CNT charge density, lateral electric-field, $I_{DS}-V_{GS}$ transfer characteristics, subthreshold swing, current spectrum, and sensitivity. Moreover, a parametric analysis is performed to study the impact of ultrascaling issue on the sensitivity behavior. The obtained results empower the proposed nanobiosensor to be considered as a promising candidate for high-performance label-free DNA sensing applications at the nanoscale domain, where the dimensions of bio-measurands are comparable with those of nanobiosensors.

Keywords: label free; carbon nanotube; dna; nanotube field

Journal Title: IEEE Sensors Journal
Year Published: 2019

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