LAUSR

We report ultra-selective zinc stannate nano cubes (ZnSnO₃) modified glassy carbon electrode (GCE) for simultaneous detection of Uric Acid (UA) and Dopamine (DA) using differential pulse voltammetry (DPV) technique. The ZnSnO₃ nano cubes were synthesized via one-pot hydrothermal technique. The orthorhombic phase formation of nano cubes structured ZnSnO₃ was confirmed through X-ray diffraction (XRD) and scanning electron microscopy (SEM) imaging. The sensor exhibited very distinct oxidation potentials and excellent sensitivity with wide dynamic ranges of detection ranging from 10 nM to $5~\mu \text{M}$ and $1~\mu \text{M}$ to 5 mM with a very low limit of detections of 2.6 nM and 550 nM towards DA and UA respectively. The sensing mechanism can be ascribed to the simultaneous electro-oxidation process of DA and UA at the 3d orbital SnO₆ octahedra sites facilitated with the Sn²⁺/Sn⁴⁺ oxidation states of Sn in line with the stress induced electrical property transformation of ZnSnO₃ due to its piezoelectric nature. The as fabricated ZnSnO₃/GCE sensor was further successfully evaluated for simultaneous detection of UA and DA in the simulated blood serum samples. This simple strategy for developing ZnSnO₃ perovskite modified electrode paves way to develop electrochemical sensing platforms for bioanalytical applications.