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A flow cytometer chip fabricated in 65-nm standard CMOS technology embedded into a microfluidic channel is presented. The chip detects cells specifically tagged with magnetic labels by demodulating the change… Click to show full abstract
A flow cytometer chip fabricated in 65-nm standard CMOS technology embedded into a microfluidic channel is presented. The chip detects cells specifically tagged with magnetic labels by demodulating the change in coupling between an excitation coil and a pickup coil of a differential spiral transformer. Operation of the flow cytometer cartridge is verified for the detection of SKBR-3 breast cancer cells tagged with manganese ferrite magnetic labels using EpCAM-biotin-streptavidin chemistry. Magnetic labels of different materials are classified by the difference in the phase of their complex susceptibility.
Journal Title: IEEE Journal of Solid-State Circuits
Year Published: 2017
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