LAUSR

Obviously, genetic differences, including mutations and polymorphisms, can play an important role in viral infections, So in this case-control study, which contained 81 Human T-cell leukemia virus type 1(HTLV-1) asymptomatic carriers (ACs) and 162 healthy controls (HCs), the rs4143815 polymorphism of PDL1 gene investigated. This polymorphism is the site of miR-570 binding and it can influence immune system responses. The rs4143815 polymorphism was evaluated by allele-specific polymerase chain reaction (AS-PCR) and proviral load (PVL) levels by quantitative real-time PCR (q PCR). The results demonstrated that C allele (p=0.027) and CC genotype (p=0.031) of rs4143815 polymorphism was significantly higher in ACs than HCs group also, the PVL in ACs with C allele (p=0.020) was higher significantly. Thus, the rs4143815 polymorphism can play a vital role in HTLV-1 infection. This article is protected by copyright. All rights reserved.