LAUSR

Prevention of the disease severity seems critical for mortality reduction of Coronavirus (CoV) disease-19. The neutrophils play a key role in the induction of severity. We here propose inhibition of neutrophil activation and/or cascade reactions of complement leading to this cell activation at the early phase of the disease as a potential tool to inhibit aggravation of the disease. We emphasize the need of appropriate timing for intervention as follows. 1) The intervention at the very early stage of severe acute respiratory syndrome-CoV-2 infection may harm the defensive host response to the infection because of a critical function of neutrophils in this response, and 2) intervention at too late a stage will not stop the infiltration of fully activated neutrophils that produce large amounts of toxic substances. This article is protected by copyright. All rights reserved.