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A novel low‐density lipoprotein/fibrinogen apheresis method for chronic limb‐threatening ischemia in patients with poor options for revascularization: A multicenter, single‐arm clinical trial

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Low‐density lipoprotein (LDL) apheresis is a treatment option for patients with unhealed chronic limb‐threatening ischemia (CLTI) after revascularization. The newly developed AS‐25 is a direct hemoperfusion‐type apheresis device that differs… Click to show full abstract

Low‐density lipoprotein (LDL) apheresis is a treatment option for patients with unhealed chronic limb‐threatening ischemia (CLTI) after revascularization. The newly developed AS‐25 is a direct hemoperfusion‐type apheresis device that differs from conventional LDL apheresis therapy and is designed to specifically adsorb both LDL‐C and fibrinogen. We evaluate the efficacy and safety of AS‐25.

Keywords: threatening ischemia; apheresis; chronic limb; limb threatening; low density; density lipoprotein

Journal Title: Therapeutic Apheresis and Dialysis
Year Published: 2022

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