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Bacterial minicells to the rescue: cyto‐Immunotherapy for the treatment of late stage cancers with minimal to no toxicity

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i. a magic bullet with a single drug able to kill tumour cells, ii. a magic bomb combining surgery, radiotherapy and chemotherapy to achieve higher levels of anti-tumour efficacy, iii.… Click to show full abstract

i. a magic bullet with a single drug able to kill tumour cells, ii. a magic bomb combining surgery, radiotherapy and chemotherapy to achieve higher levels of anti-tumour efficacy, iii. monoclonal antibodies to receptors over-expressed on tumour cell surface to reduce toxic side effects and achieve tumour-targeted therapy, iv. synthetic nanoparticles and polymers to package drugs and deliver them to tumour cells to reduce toxic side effects and achieve higher anti-tumour efficacy, v. molecularly targeted drugs that targeted specific oncogenic proteins to avoid killing normal cells, vi. checkpoint inhibitor immunotherapy to reactivate the patient’s own immune system, vii. Chimeric antigen receptors to give T cells the ability to target a tumour-specific protein and T cell activating function in a single receptor.

Keywords: tumour; immunotherapy treatment; bacterial minicells; minicells rescue; rescue cyto; cyto immunotherapy

Journal Title: Microbial Biotechnology
Year Published: 2021

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