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Type 2 diabetes (T2D) is characterized by a progressive deterioration of β‐cell function with a continuous decline in insulin secretion. Glucokinase (GCK) facilitates the rate‐limiting step of glycolysis in pancreatic… Click to show full abstract
Type 2 diabetes (T2D) is characterized by a progressive deterioration of β‐cell function with a continuous decline in insulin secretion. Glucokinase (GCK) facilitates the rate‐limiting step of glycolysis in pancreatic β‐cells, to acquire the proper glucose‐stimulated insulin secretion. Multiple glucokinase activators (GKAs) have been developed and clinically tested. However, the dynamic change of human pancreatic GCK expression during T2D progression has not been investigated.
Keywords:
expression increased;
type diabetes;
type;
glucokinase expression;
cell glucokinase
Journal Title: Journal of Diabetes
Year Published: 2023
Link to full text (if available)
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Journal Title: Journal of Diabetes
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!