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Induction chemotherapy followed by radical chemoradiotherapy for patients with stage IV non‐metastatic nasopharyngeal carcinoma: 11‐Year Experience in a tertiary centre

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T4 nasopharyngeal carcinoma (NPC) with close proximity to critical organs at risk (OARs) is usually underdosed during radiotherapy in order to respect radiation constraints. N3 disease has high risk of… Click to show full abstract

T4 nasopharyngeal carcinoma (NPC) with close proximity to critical organs at risk (OARs) is usually underdosed during radiotherapy in order to respect radiation constraints. N3 disease has high risk of distant metastasis. Induction chemotherapy (IC) provides advantages of sparing of OARs during subsequent chemoradiotherapy (CCRT) and early eradication of micrometastasis. However, factors predicting successes of IC in this patient group are not well‐studied.

Keywords: nasopharyngeal carcinoma; induction chemotherapy; chemotherapy followed; chemoradiotherapy

Journal Title: Journal of Medical Imaging and Radiation Oncology
Year Published: 2022

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