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Pro‐inflammatory cytokine single nucleotide polymorphisms in Kawasaki disease

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Kawasaki disease (KD) is a systemic vasculitis of children associated with cardiovascular sequelae. Proinflammatory cytokines play a major role in KD pathogenesis. However, their role is both influenced and modified… Click to show full abstract

Kawasaki disease (KD) is a systemic vasculitis of children associated with cardiovascular sequelae. Proinflammatory cytokines play a major role in KD pathogenesis. However, their role is both influenced and modified by regulatory T‐cells. IL‐1 gene cluster, IL‐6 and TNF‐α polymorphisms have shown significant associations with some vasculitides. Herein we investigated their role in KD.

Keywords: cytokine single; inflammatory cytokine; kawasaki; kawasaki disease; pro inflammatory

Journal Title: International Journal of Rheumatic Diseases
Year Published: 2018

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