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Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease. Prostaglandins E2 (PGE2), the product of the cyclo‐oxygenase 2 (COX‐2) enzyme, has critical roles in the etiology of autoimmune diseases.… Click to show full abstract
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease. Prostaglandins E2 (PGE2), the product of the cyclo‐oxygenase 2 (COX‐2) enzyme, has critical roles in the etiology of autoimmune diseases. PGE2 level is controlled by a balance between its synthesis mediator (COX‐2 enzyme) and its catabolic key enzyme (15‐hydroxyprostaglandin dehydrogenase [15‐PGDH] enzyme). In the present study, the associations of genotypic polymorphisms in COX‐2 and 15‐PGDH with SLE were investigated.
Journal Title: International Journal of Rheumatic Diseases
Year Published: 2020
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