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Relationship of Wnt pathway activity and organ involvement in scleroderma types

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Scleroderma (SSc) is a chronic inflammatory autoimmune disease characterized by fibrosis in the skin and internal organs. In SSc, the heart, lung, kidney, gastrointestinal (GIS) system, muscle, and peri‐articular structures… Click to show full abstract

Scleroderma (SSc) is a chronic inflammatory autoimmune disease characterized by fibrosis in the skin and internal organs. In SSc, the heart, lung, kidney, gastrointestinal (GIS) system, muscle, and peri‐articular structures are damaged. There is no study of the relationship between SSc type, stage, pathogenesis, organ involvement, and Wnt signaling. In this study, we aimed to show the relationship of the Wnt gene family and antagonists in SSc subtypes and different organ involvement.

Keywords: organ involvement; relationship; relationship wnt; pathway activity; wnt pathway; activity organ

Journal Title: International Journal of Rheumatic Diseases
Year Published: 2020

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