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Impact of folic acid on regulatory B lymphocytes from patients with systemic lupus erythematosus in vitro

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Epigenetic modifications of genomes are of particular interest as numerous studies indicate the correlation between DNA methylation and the development of systemic lupus. As a major methyl group donor, folic… Click to show full abstract

Epigenetic modifications of genomes are of particular interest as numerous studies indicate the correlation between DNA methylation and the development of systemic lupus. As a major methyl group donor, folic acid is an important participant in this process. The aim of this study is to determine the effect of low or high dose folate co‐culturing with peripheral blood mononuclear cells (PBMCs) on the secretion of interleukin (IL)10 from regulatory cells from lupus patients or from healthy volunteers.

Keywords: folic acid; acid regulatory; regulatory lymphocytes; impact folic; systemic lupus

Journal Title: International Journal of Rheumatic Diseases
Year Published: 2022

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