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Genetically Predicted Plasma Metabolome Mediates the Causal Link Between Immune Cells and Risk of Gout

Gout is a prevalent metabolic disorder characterized by a multifaceted process of development. Recent research has emphasized a robust correlation between the immune response and gout. Nevertheless, it is still… Click to show full abstract

Gout is a prevalent metabolic disorder characterized by a multifaceted process of development. Recent research has emphasized a robust correlation between the immune response and gout. Nevertheless, it is still uncertain if this connection is causative. Hence, the objective of this study was to investigate the causal relationship between immune cells and gout, while also analyzing the role of the plasma metabolome as metabolic mediators in this biological process.

Keywords: gout; immune cells; metabolome mediates; plasma metabolome; predicted plasma; genetically predicted

Journal Title: International Journal of Rheumatic Diseases
Year Published: 2025

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