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Snail acetylation by histone acetyltransferase p300 in lung cancer

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Epithelial to mesenchymal transition (EMT) is a complex and dynamic molecular event in lung cancer metastasis that has not yet been thoroughly investigated. EMT transcriptional factors, such as Snail, play… Click to show full abstract

Epithelial to mesenchymal transition (EMT) is a complex and dynamic molecular event in lung cancer metastasis that has not yet been thoroughly investigated. EMT transcriptional factors, such as Snail, play a central role in regulation of the EMT process. In this study, we sought to identify an association between p300 and Snail in lung cancer, as well as the engagement of p300 in Snail acetylation.

Keywords: cancer; snail acetylation; p300; lung cancer

Journal Title: Thoracic Cancer
Year Published: 2017

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