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Molecular mechanism of acquired drug resistance in the EGFR‐TKI resistant cell line HCC827‐TR

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The first‐line standard treatment of non‐small cell lung cancer (NSCLC) with EGFR mutation is EGFR‐tyrosine kinase inhibitors (TKIs). However, most patients will develop acquired resistance after 9–13 months. This study investigated… Click to show full abstract

The first‐line standard treatment of non‐small cell lung cancer (NSCLC) with EGFR mutation is EGFR‐tyrosine kinase inhibitors (TKIs). However, most patients will develop acquired resistance after 9–13 months. This study investigated novel molecular mechanisms of acquired resistance to EGFR‐TKIs to identify a potential new treatment for EGFR‐TKI resistant NSCLC patients.

Keywords: egfr; tki resistant; resistance egfr; line; resistance; egfr tki

Journal Title: Thoracic Cancer
Year Published: 2020

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