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TMEM107 inhibits EMT and invasion of NSCLC through regulating the Hedgehog pathway

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Transmembrane protein 107 (TMEM107) is a key regulator of the cilium composition and Hedgehog signaling. Lower TMEM107 gene copies are correlated with poor prognosis in non‐small cell lung carcinoma (NSCLC).… Click to show full abstract

Transmembrane protein 107 (TMEM107) is a key regulator of the cilium composition and Hedgehog signaling. Lower TMEM107 gene copies are correlated with poor prognosis in non‐small cell lung carcinoma (NSCLC). However, TMEM107 protein expression, localization, and function in NSCLC remain unclear.

Keywords: tmem107 inhibits; invasion nsclc; emt invasion; tmem107; inhibits emt; nsclc regulating

Journal Title: Thoracic Cancer
Year Published: 2020

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