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GPR12 inhibits migration and promotes apoptosis in esophageal cancer and hypopharyngeal cancer cells

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G protein‐coupled receptor 12 (GPR12) is an orphan receptor with no confirmed endogenous ligands. It plays important roles in both physiological and pathological conditions such as neurogenesis and neural inflammation.… Click to show full abstract

G protein‐coupled receptor 12 (GPR12) is an orphan receptor with no confirmed endogenous ligands. It plays important roles in both physiological and pathological conditions such as neurogenesis and neural inflammation. However, it remains unclear whether GPR12 regulates carcinogenesis and progression in head and neck squamous cell carcinoma (HNSCC), such as esophageal cancer (EC) and hypopharyngeal cancer (HC).

Keywords: esophageal cancer; gpr12 inhibits; cancer hypopharyngeal; hypopharyngeal cancer; cancer

Journal Title: Thoracic Cancer
Year Published: 2021

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