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Polymorphic mutations in the polb gene promoter and their impact on transcriptional activity

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DNA polymerase β is one of the key enzymes involved in DNA damage repair and its proper expression is strictly controlled within different cells. We previously reported that three genetic… Click to show full abstract

DNA polymerase β is one of the key enzymes involved in DNA damage repair and its proper expression is strictly controlled within different cells. We previously reported that three genetic mutations in the promoter region of the polb gene are prevalent in the Chinese Han population and two types of mutation are associated with thymic hyperplasia. The purpose of this study was to explore whether other mutated sites exist within the promoter region of the polb gene.

Keywords: promoter; polymorphic mutations; mutations polb; gene promoter; polb gene

Journal Title: Thoracic Cancer
Year Published: 2022

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